This study's purpose was to implement a comprehensive program to reduce pedestrian deaths and injuries among pedestrians in a large urban environment. Miami-Dade County, Florida, was selected as the study's focus. High-crash locations were targeted for countermeasure implementation and analysis. With pedestrian crash data (1996-2001), four zones within the county were identified as having abnormally high pedestrian crash experience. On the basis of crash characteristics and pedestrian factors (age, ethnicity), 16 education, enforcement, and engineering treatments were implemented to reduce pedestrian crashes in the four zones and countywide. A before-and-alter study was used with three control groups to evaluate the effects of the pedestrian safety program on pedestrian crashes. A 3-year "after" period was used (2002-2004). Multivariate intervention auto regressive integrated moving average time-series analysis was used, along with nonparametric U-tests to test for statistically significant differences in pedestrian crash experience. Results showed that at the peak of the program effects in 2003 and 2004, the pedestrian safety program reduced countywide pedestrian crash rates by anywhere from 8.5% to 13.3%, depending on which control group was used. These effects translate to approximately 180 fewer crashes annually in the county, or 360 pedestrian crashes reduced for 2003 and 2004 combined, based on the more conservative 8.5% crash reduction. Countywide, the greatest crash reductions were found among children and adults as a result of the program. Educational and other measures to reduce crashes involving older pedestrians showed no effect A number of lessons learned were identified for future program implementation.