Evaluation of lean body weight equation by dual-energy X-ray absorptiometry measures

Lauren M. Beckman, Joseph I. Boullata, Paige L. Fisher, Charlene W. Compher, Carrie P. Earthman

Research output: Contribution to journalArticle

Abstract

Background: When managing patients with disorders that require clinical intervention, a practical assessment of body habitus is valued. The Duffull-Green lean body weight (LBW) equation was derived and validated in adults across a wide body mass index (BMI) range. Whether this predictive equation will perform well in patients at BMI extremes or perform better than a widely used empiric "ideal" body weight (IBW) equation is unknown. Materials and Methods: Calculated LBW and calculated IBW were each compared with the dual-energy x-ray absorptiometry (DXA)-derived lean body mass (LBM) by simple linear regression. A mixed model was used to determine how well the LBW equation performed over time in patients with more than 1 DXA measurement. Results: At time 0, 32 patients were 18-67 years old, and all were obese (BMI: 36-65 kg/m2), while the remaining 7 had parenteral nutrition-dependent intestinal failure (BMI: 17-25 kg/m2). A subset of patients underwent bariatric surgery after time 0 (BMI at follow-up: 22-49 kg/m2). The LBW equation was a predictor of LBM (R2 = 0.67, P <.0001), while the IBW equation was not (R2 = 0.04, P =.25). The LBW equation remained a predictor of LBM over time (P <.0001) without significant interaction by number of months since time 0. Conclusion: The Duffull-Green LBW equation successfully predicted lean body mass in a patient population with a wide range of BMIs at both a single point in time and after considerable weight loss. In the clinical setting, an equation that performs well in various disease states and body sizes is advantageous.

LanguageEnglish (US)
Pages392-397
Number of pages6
JournalJournal of Parenteral and Enteral Nutrition
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2017

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Photon Absorptiometry
Body Weight
Body Mass Index
Ideal Body Weight
X-Rays
Bariatric Surgery
Parenteral Nutrition
Body Size
Weight Loss
Linear Models
Population

Keywords

  • adult
  • body composition
  • nutrition
  • nutrition assessment

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Evaluation of lean body weight equation by dual-energy X-ray absorptiometry measures. / Beckman, Lauren M.; Boullata, Joseph I.; Fisher, Paige L.; Compher, Charlene W.; Earthman, Carrie P.

In: Journal of Parenteral and Enteral Nutrition, Vol. 41, No. 3, 01.03.2017, p. 392-397.

Research output: Contribution to journalArticle

Beckman, Lauren M. ; Boullata, Joseph I. ; Fisher, Paige L. ; Compher, Charlene W. ; Earthman, Carrie P./ Evaluation of lean body weight equation by dual-energy X-ray absorptiometry measures. In: Journal of Parenteral and Enteral Nutrition. 2017 ; Vol. 41, No. 3. pp. 392-397
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