Abstract
Objective: The LeadCare Ultra® (LCU) was compared to inductively coupled plasma mass spectrometry ICP-MS for use as a screening test for elevated blood lead levels (BLLs) in capillary samples from children. Methods: During the validation, method comparisons between LCU and ICP-MS were analyzed to determine the bias above, near, and below the BLL cut-off of 5 μg/dL. Additionally, capillary samples that screened positive by LCU (above the 5 μg/dL cut-off) were compared to venous samples analyzed by ICP-MS for confirmatory testing. Results: LCU had a positive bias (1.7 μg/dL) below the cut-off of BLL <5 μg/dL, no bias near the cut-off from BLL 5–10 μg/dL, and a negative bias (−0.8 μg/dL) for BLL >10 μg/dL compared to ICP-MS. Of the 59 capillary samples that screened positive by LCU between May of 2017 to April of 2018, 19 were confirmed positive by ICP-MS, 30 were confirmed negative by ICP-MS, and 10 did not have a confirmed result. Conclusion: The LCU assay is an acceptable screen for capillary samples with the BLL cut-off of 5 μg/dL.
Original language | English (US) |
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Pages (from-to) | 95-99 |
Number of pages | 5 |
Journal | Clinical Biochemistry |
Volume | 66 |
DOIs | |
State | Published - Apr 2019 |
Bibliographical note
Publisher Copyright:© 2019 The Canadian Society of Clinical Chemists
Keywords
- Children
- ICP-MS
- Lead
- LeadCare
- Screen