Evaluation of hyperthermia of magnetic nanoparticles by dehydrating DNA

Lina Yu, Jinming Liu, Kai Wu, Todd Klein, Yong Jiang, Jian Ping Wang

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33 Scopus citations


A method based on the thermodynamic equilibrium reached between the hybridization and denaturation of double-stranded DNA (ds-DNA) is opened up to evaluate the hyperthermia performance of magnetic nanoparticles (MNPs). Two kinds of MNPs with different sizes and magnetic performance are chosen, and their temperature increments at the surface area under an alternating magnetic field (AMF) are calculated and compared through the concentration variation of ds-DNA modified on the surface. The temperature difference between the surface area of MNPs and bulk solution is also investigated, which can reach as high as 57.8°C whenAMFapplied for 300 s. This method provides a direct path way of comparison hyperthermia ability of MNPs, and serves as a good reference to choose MNPs and decides the therapy parameters based on the unique drug response of individual patient.

Original languageEnglish (US)
Article number7216
JournalScientific reports
StatePublished - Nov 27 2014

Bibliographical note

Funding Information:
Lina Yu was supported by China Scholar Council. The work was partially supported by the NSF MRSEC program facility, Institute on Environment fellow program and Institute of Engineering in Medicine seed grant at the University of Minnesota. The author Y.J. thanks the financial support from the National Basic Research Program of China (Grant No. 2015CB921502, 2012CB932702).


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