Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy

Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group

doi:10.1086/340819

Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy

Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.

Original language	English (US)
Pages (from-to)	1798-1802
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	185
Issue number	12
DOIs	https://doi.org/10.1086/340819
State	Published - Jun 15 2002
Externally published	Yes

Bibliographical note

Funding Information:
Received 28 November 2001; revised 25 February 2002; electronically published 31 May 2002. Financial support: National Institutes of Health (grants HR-96037, HR-96038, HR-96039, HR-96040, HR-96041, HR-96042, HR-96043, RR-00188, RR-00533, RR-00071, RR-00645, RR-00865, and RR-00043). a Study group members are listed after the text. Reprints or correspondence: Dr. Hal B. Jenson, University of Texas Health Science Center, Dept. of Pediatrics, MC 7811, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900 ([email protected]).

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SDG 3 Good Health and Well-being

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10.1086/340819

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@article{bc232c96f36b437ab8b697bc21eb93c6,

title = "Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy",

abstract = "In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95\% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.",

author = "\{Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group\} and Jenson, \{Hal B.\} and Gauntt, \{Charles J.\} and Easley, \{Kirk A.\} and Jane Pitt and Lipshultz, \{Steven E.\} and \{Mc Intosh\}, Kenneth and Shearer, \{William T.\} and Anthony Kalica and Elaine Sloand and George Sopko and Margaret Wu and Robert Mellins and William Shearer and Gail Demmler and Linda Davis and Debra Mooneyham and Teresa Tonsberg and Steven Lipshultz and \{Mc Intosh\}, Kenneth and Janice Hunter and Ellen Cooper and Suzanne Steinbach and Karen Lewis and Meyer Kattan and David MHodes and Diane Carp and Stephen Heaton and Worth, \{Mary Ann\} and Karen Lewis and Robert Mellins and Kim Geromanos and Samuel Kaplan and Yvonne Bryson and Helene Cohen and Joseph Church and Arnold Platzker and Lucy Kunzman and Andrea Kovacs and Lynn Fukushima and Jenson, \{Hal B.\} and Yasmin Ench and Kirk Easley and Michael Kutner and Mark Schluchter and Richard Martin and Johanna Goldfarb and Douglas Moodie and Cindy Chen and Victoria Konig and Sunil Rao",

note = "Funding Information: Received 28 November 2001; revised 25 February 2002; electronically published 31 May 2002. Financial support: National Institutes of Health (grants HR-96037, HR-96038, HR-96039, HR-96040, HR-96041, HR-96042, HR-96043, RR-00188, RR-00533, RR-00071, RR-00645, RR-00865, and RR-00043). a Study group members are listed after the text. Reprints or correspondence: Dr. Hal B. Jenson, University of Texas Health Science Center, Dept. of Pediatrics, MC 7811, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900 ([email protected]).",

year = "2002",

month = jun,

day = "15",

doi = "10.1086/340819",

language = "English (US)",

volume = "185",

pages = "1798--1802",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "12",

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TY - JOUR

T1 - Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy

AU - Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group

AU - Jenson, Hal B.

AU - Gauntt, Charles J.

AU - Easley, Kirk A.

AU - Pitt, Jane

AU - Lipshultz, Steven E.

AU - Mc Intosh, Kenneth

AU - Shearer, William T.

AU - Kalica, Anthony

AU - Sloand, Elaine

AU - Sopko, George

AU - Wu, Margaret

AU - Mellins, Robert

AU - Shearer, William

AU - Demmler, Gail

AU - Davis, Linda

AU - Mooneyham, Debra

AU - Tonsberg, Teresa

AU - Lipshultz, Steven

AU - Mc Intosh, Kenneth

AU - Hunter, Janice

AU - Cooper, Ellen

AU - Steinbach, Suzanne

AU - Lewis, Karen

AU - Kattan, Meyer

AU - MHodes, David

AU - Carp, Diane

AU - Heaton, Stephen

AU - Worth, Mary Ann

AU - Lewis, Karen

AU - Mellins, Robert

AU - Geromanos, Kim

AU - Kaplan, Samuel

AU - Bryson, Yvonne

AU - Cohen, Helene

AU - Church, Joseph

AU - Platzker, Arnold

AU - Kunzman, Lucy

AU - Kovacs, Andrea

AU - Fukushima, Lynn

AU - Jenson, Hal B.

AU - Ench, Yasmin

AU - Easley, Kirk

AU - Kutner, Michael

AU - Schluchter, Mark

AU - Martin, Richard

AU - Goldfarb, Johanna

AU - Moodie, Douglas

AU - Chen, Cindy

AU - Konig, Victoria

AU - Rao, Sunil

N1 - Funding Information: Received 28 November 2001; revised 25 February 2002; electronically published 31 May 2002. Financial support: National Institutes of Health (grants HR-96037, HR-96038, HR-96039, HR-96040, HR-96041, HR-96042, HR-96043, RR-00188, RR-00533, RR-00071, RR-00645, RR-00865, and RR-00043). a Study group members are listed after the text. Reprints or correspondence: Dr. Hal B. Jenson, University of Texas Health Science Center, Dept. of Pediatrics, MC 7811, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900 ([email protected]).

PY - 2002/6/15

Y1 - 2002/6/15

N2 - In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.

AB - In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.

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UR - https://www.scopus.com/pages/publications/0037097545#tab=citedBy

U2 - 10.1086/340819

DO - 10.1086/340819

M3 - Article

C2 - 12085328

AN - SCOPUS:0037097545

SN - 0022-1899

VL - 185

SP - 1798

EP - 1802

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy

Abstract

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