TY - JOUR
T1 - Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy
AU - Pediatric Pulmonary and Cardiovascular Complications of HIV-1 Infection Study Group
AU - Jenson, Hal B.
AU - Gauntt, Charles J.
AU - Easley, Kirk A.
AU - Pitt, Jane
AU - Lipshultz, Steven E.
AU - Mc Intosh, Kenneth
AU - Shearer, William T.
AU - Kalica, Anthony
AU - Sloand, Elaine
AU - Sopko, George
AU - Wu, Margaret
AU - Mellins, Robert
AU - Shearer, William
AU - Demmler, Gail
AU - Davis, Linda
AU - Mooneyham, Debra
AU - Tonsberg, Teresa
AU - Lipshultz, Steven
AU - Mc Intosh, Kenneth
AU - Hunter, Janice
AU - Cooper, Ellen
AU - Steinbach, Suzanne
AU - Lewis, Karen
AU - Kattan, Meyer
AU - MHodes, David
AU - Carp, Diane
AU - Heaton, Stephen
AU - Worth, Mary Ann
AU - Lewis, Karen
AU - Mellins, Robert
AU - Geromanos, Kim
AU - Kaplan, Samuel
AU - Bryson, Yvonne
AU - Cohen, Helene
AU - Church, Joseph
AU - Platzker, Arnold
AU - Kunzman, Lucy
AU - Kovacs, Andrea
AU - Fukushima, Lynn
AU - Jenson, Hal B.
AU - Ench, Yasmin
AU - Easley, Kirk
AU - Kutner, Michael
AU - Schluchter, Mark
AU - Martin, Richard
AU - Goldfarb, Johanna
AU - Moodie, Douglas
AU - Chen, Cindy
AU - Konig, Victoria
AU - Rao, Sunil
N1 - Funding Information:
Received 28 November 2001; revised 25 February 2002; electronically published 31 May 2002. Financial support: National Institutes of Health (grants HR-96037, HR-96038, HR-96039, HR-96040, HR-96041, HR-96042, HR-96043, RR-00188, RR-00533, RR-00071, RR-00645, RR-00865, and RR-00043). a Study group members are listed after the text. Reprints or correspondence: Dr. Hal B. Jenson, University of Texas Health Science Center, Dept. of Pediatrics, MC 7811, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900 ([email protected]).
PY - 2002/6/15
Y1 - 2002/6/15
N2 - In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.
AB - In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.
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U2 - 10.1086/340819
DO - 10.1086/340819
M3 - Article
C2 - 12085328
AN - SCOPUS:0037097545
SN - 0022-1899
VL - 185
SP - 1798
EP - 1802
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -
