Evaluation of cortical current density imaging methods using intracranial electrocorticograms and functional MRI

Xiaoxiao Bai, Vernon L. Towle, Eric J. He, Bin He

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Objective: EEG source imaging provides important information regarding the underlying neural activity from noninvasive electrophysiological measurements. The aim of the present study was to evaluate source reconstruction techniques by means of the intracranial electrocorticograms (ECoGs) and functional MRI. Methods: Five source imaging algorithms, including the minimum norm least square (MNLS), LORETA with Lp-norm (p equal to 1, 1.5 and 2), sLORETA, the minimum Lp-norm (p equal to 1 and 1.5; when p = 2, the MNLS method is mathematically equivalent to the minimum Lp-norm) and L1-norm (the linear programming) methods, were evaluated in a group of 10 human subjects, in a paradigm with somatosensory stimulation. Cortical current density (CCD) distributions were estimated from the scalp somatosensory evoked potentials (SEPs), at approximately 30 ms following electrical stimulation of median nerve at the wrist. Realistic geometry boundary element head models were constructed from the MRIs of each subject and used in the CCD analysis. Functional MRI results obtained from a motor task and sensory stimulation in all subjects were used to identify the central sulcus, motor and sensory areas. In three patients undergoing neurosurgical evaluation, ECoGs were recorded in response to the somatosensory stimulation, and were used to help determine the central sulcus and the sensory cortex. Results: The CCD distributions estimated by the Lp-norm and LORETA-Lp methods were smoother when the p values were high. The LORETA based on the L1-norm performed better than the LORETA-L2 method for imaging well localized sources such as the P30 component of the SEP. The mean and standard deviation of the distance between the location of maximum CCD value and the central sulcus, estimated by the minimum Lp-norm (with p equal to 1), L1-norm (the Linear programming) and LORETA-Lp (with p equal to 1) methods, were 4, 7, 7 mm and 3, 4, 2 mm, respectively (after converting into Talairach coordinates). The mean and standard deviation of the aforementioned distance, estimated by the MNLS, LORETA with Lp-norm (p equal to 1.5 and 2.0), sLORETA and the minimum Lp-norm (p equal to 1.5) methods, were over 11 mm and 6 mm, respectively. Conclusions: The present experimental study suggests that L1-norm-based algorithms provide better performance than L2 and L1.5-norm-based algorithms, in the context of CCD imaging of well localized sources induced by somatosensory electrical stimulation of median nerve at the wrist.

Original languageEnglish (US)
Pages (from-to)598-608
Number of pages11
JournalNeuroImage
Volume35
Issue number2
DOIs
StatePublished - Apr 1 2007

Bibliographical note

Funding Information:
The authors thank Dr. Wim van Drongelen, Mr. Christopher Wilke, Mr. Zhongming Liu and Mr. Ding Lei for useful discussions. This work was supported in part by NIH R01EB00178, NIHR013001A2, NSF BES-0411898, the Biomedical EngineeringInstitute and Supercomputing Institute of the University of Minnesota and the Brain Research Foundation.

Keywords

  • Brain imaging
  • Central sulcus
  • Cortical current density
  • High resolution EEG
  • Inverse Problem
  • Sensory cortex
  • Somatosensory evoked potentials
  • Source imaging

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