Evaluation of Blob Theory for the Diffusion of DNA in Nanochannels

Damini Gupta, Aditya Bikram Bhandari, Kevin Dorfman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We have measured the diffusivity of λ-DNA molecules in approximately square nanochannels with effective sizes ranging from 117 to 260 nm at moderate ionic strength. The experimental results do not agree with the nondraining scaling predicted by blob theory. Rather, the data are consistent with the predictions of previous simulations of the Kirkwood diffusivity of a discrete wormlike chain model, without the need for any fitting parameters.

Original languageEnglish (US)
Pages (from-to)1748-1755
Number of pages8
Issue number5
StatePublished - Mar 13 2018

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© 2018 American Chemical Society.


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