Evaluation of analgesic efficacy and associated plasma concentration of tramadol and O-desmethyltramadol following oral administration post ovariohysterectomy

E. M. Goudie-DeAngelis, Kerry J. Woodhouse, M. R. Raffe, F. H. David

Research output: Contribution to journalArticle

Abstract

Tramadol is used in both human and veterinary medicine to treat postoperative pain. In human subjects, variation in metabolism of tramadol has led to inconsistent analgesia in some individuals. The purpose of the current study was to evaluate tramadol as a sole postoperative analgesic and to compare drug plasma concentration to clinical pain score. A high or low dose of tramadol was randomly assigned and administered to 14 mixed breed female dogs after ovariohysterectomy. The Short-Form of the Glasgow Composite Measure Pain Scale was used for pain evaluation post-operatively. Plasma was collected for evaluation of tramadol and O-desmethyltramadol concentrations. The effect of weight and dose on pain scores as well as how pain score correlated with plasma concentration of tramadol and O-desmethyltramadol was evaluated. A significant difference in pain score was noted between doses when weight classes were pooled. The plasma concentrations did not correlate with pain score. Based on our results, the use of tramadol as a sole analgesic agent provides inadequate postoperative pain control but further evaluation of tramadol as a postoperative analgesic agent is needed.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalInternational Journal of Applied Research in Veterinary Medicine
Volume14
Issue number1
StatePublished - Jan 1 2016

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Tramadol
spaying
analgesics
oral administration
Oral Administration
Analgesics
pain
Pain
Postoperative Pain
dosage
Weights and Measures
Veterinary Medicine
O-demethyltramadol
Analgesia
analgesia
veterinary medicine
medicine
Dogs
drugs
metabolism

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Evaluation of analgesic efficacy and associated plasma concentration of tramadol and O-desmethyltramadol following oral administration post ovariohysterectomy. / Goudie-DeAngelis, E. M.; Woodhouse, Kerry J.; Raffe, M. R.; David, F. H.

In: International Journal of Applied Research in Veterinary Medicine, Vol. 14, No. 1, 01.01.2016, p. 105-113.

Research output: Contribution to journalArticle

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