Aims: The purpose of this multicentre clinical randomized controlled blinded prospective trial was to determine whether an inspiratory impedance threshold device (ITD), when used in combination with active compression-decompression (ACD) cardiopulmonary resuscitation (CPR), would improve survival rates in patients with out-of-hospital cardiac arrest. Methods and results: Patients were randomized to receive either a sham (n=200) or an active impedance threshold device (n=200) during advanced cardiac life support performed with active compression-decompression cardiopulmonary resuscitation. The primary endpoint of this study was 24 h survival. The 24 h survival rates were 44/200 (22%) with the sham valve and 64/200 (32%) with the active valve (P=0.02). The number of patients who had a return of spontaneous circulation (ROSC), intensive care unit (ICU) admission, and hospital discharge rates was 77 (39%), 57 (29%), and 8 (4%) in the sham valve group versus 96 (48%) (P=0.05), 79 (40%) (P=0.02), and 10 (5%) (P=0.6) in the active valve group. Six out of ten survivors in the active valve group and 1/8 survivors in the sham group had normal neurological function at hospital discharge (P=0.1). Conclusion: The use of an impedance valve in patients receiving active compression-decompression cardiopulmonary resuscitation for out-of-hospital cardiac arrest significantly improved 24 h survival rates.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Jun 2004|
Bibliographical noteFunding Information:
This study was funded in part by Advanced Circulatory Systems Incorporated (formerly CPRx LLC) 7615 Golden Triangle Dr., Suite A, Technology Park, Eden Prairie, MN 55344, USA.
- Active compression-decompression
- Cardiac arrest
- Cardiopulmonary resuscitation (CPR)
- Compresão-descompressão activa
- Impedance threshold device
- Paragem cardíaca
- Reanimação cardio-pulmonar (CPR)