Evaluation of a home-based colorectal cancer screening intervention in a rural state

Mary E. Charlton, Michelle A. Mengeling, Thorvardur R. Halfdanarson, Nader M. Makki, Ashish Malhotra, J. Stacey Klutts, Barcey T. Levy, Peter J. Kaboli

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Purpose: Distance from health care facilities can be a barrier to colorectal cancer (CRC) screening, especially for colonoscopy. Alternatively, an improved at-home stool-based screening tool, the fecal immunochemical test (FIT), requires only a single sample and has a better sensitivity-specificity balance compared to traditional guaiac fecal occult blood tests. Our objective was to determine if FITs mailed to asymptomatic, average-risk patients overdue for screening resulted in higher screening rates versus mailing educational materials alone or no intervention (ie, usual care). Methods: Veterans ages 51-64, asymptomatic, at average risk for CRC, overdue for screening and in a veterans administration (VA) catchment area covering a large rural population were randomly assigned to 3 groups: (1) education only (Ed) group: mailed CRC educational materials and a survey of screening history and preferences (N = 499); (2) FIT group: mailed the FIT, plus educational materials and survey (N = 500); and (3) usual care (UC) group: received no mailings (N = 500). Findings: At 6 months postintervention, 21% of the FIT group had received CRC screening by any method compared to 6% of the Ed group (and 6% of the UC group) (P < .0001). Of the 105 respondents from the FIT group, 71 (68%) were eligible to take the FIT. Of those, 64 (90%) completed the FIT and 8 (12%) tested positive. Conclusions: This low-intensity intervention of mailing FITs to average risk patients overdue for screening resulted in a significantly higher screening rate than educational materials alone or usual care, and may be of particular interest in rural areas.

Original languageEnglish (US)
Pages (from-to)322-332
Number of pages11
JournalJournal of Rural Health
Issue number3
StatePublished - 2014


  • Access to care
  • Colorectal cancer screening
  • Fecal immunochemical test
  • Health services research
  • Program evaluation


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