Evaluation and statistical inference for human connectomes

Franco Pestilli, Jason D. Yeatman, Ariel Rokem, Kendrick N. Kay, Brian A. Wandell

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


Diffusion-weighted imaging coupled with tractography is currently the only method for in vivo mapping of human white-matter fascicles. Tractography takes diffusion measurements as input and produces the connectome, a large collection of white-matter fascicles, as output. We introduce a method to evaluate the evidence supporting connectomes. Linear fascicle evaluation (LiFE) takes any connectome as input and predicts diffusion measurements as output, using the difference between the measured and predicted diffusion signals to quantify the prediction error. We use the prediction error to evaluate the evidence that supports the properties of the connectome, to compare tractography algorithms and to test hypotheses about tracts and connections.

Original languageEnglish (US)
Pages (from-to)1058-1063
Number of pages6
JournalNature Methods
Issue number10
StatePublished - Jan 1 2014

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