Evaluation and Management of Testosterone Deficiency: AUA Guideline

John P. Mulhall, Landon W. Trost, Robert E. Brannigan, Emily G. Kurtz, Bruce B Redmon, Kelly A. Chiles, Deborah J. Lightner, Martin M. Miner, M. Hassan Murad, Christian J. Nelson, Elizabeth A. Platz, Lakshmi V. Ramanathan, Ronald W. Lewis

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. Materials and Methods: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions (table 1 in supplementary unabridged guideline, http://jurology.com/). Results: This guideline was developed by a multi-disciplinary panel to inform clinicians on the proper assessment of patients with testosterone deficiency and the safe and effective management of men on testosterone therapy. Additional statements were developed to guide the clinician on the appropriate care of patients who are at risk for or have cardiovascular disease or prostate cancer as well as patients who are interested in preserving fertility. Conclusions: The care of testosterone deficient patients should focus on accurate assessment of total testosterone levels, symptoms, and signs as well as proper on-treatment monitoring to ensure therapeutic testosterone levels are reached and symptoms are ameliorated. Future longitudinal observational studies and clinical trials of significant duration in this space will improve diagnostic techniques and treatment of men with testosterone deficiency as well as provide more data on the adverse events that may be associated with testosterone therapy.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalJournal of Urology
Volume200
Issue number2
DOIs
StatePublished - Aug 1 2018

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Testosterone
Guidelines
Therapeutics
Evidence-Based Practice
Expert Testimony
Signs and Symptoms
Observational Studies
Prescriptions
Fertility
Longitudinal Studies
Prostatic Neoplasms
Patient Care
Cardiovascular Diseases
Clinical Trials
Research

Keywords

  • androgens
  • hypogonadism
  • men's health
  • testosterone

Cite this

Mulhall, J. P., Trost, L. W., Brannigan, R. E., Kurtz, E. G., Redmon, B. B., Chiles, K. A., ... Lewis, R. W. (2018). Evaluation and Management of Testosterone Deficiency: AUA Guideline. Journal of Urology, 200(2), 423-432. https://doi.org/10.1016/j.juro.2018.03.115

Evaluation and Management of Testosterone Deficiency : AUA Guideline. / Mulhall, John P.; Trost, Landon W.; Brannigan, Robert E.; Kurtz, Emily G.; Redmon, Bruce B; Chiles, Kelly A.; Lightner, Deborah J.; Miner, Martin M.; Murad, M. Hassan; Nelson, Christian J.; Platz, Elizabeth A.; Ramanathan, Lakshmi V.; Lewis, Ronald W.

In: Journal of Urology, Vol. 200, No. 2, 01.08.2018, p. 423-432.

Research output: Contribution to journalArticle

Mulhall, JP, Trost, LW, Brannigan, RE, Kurtz, EG, Redmon, BB, Chiles, KA, Lightner, DJ, Miner, MM, Murad, MH, Nelson, CJ, Platz, EA, Ramanathan, LV & Lewis, RW 2018, 'Evaluation and Management of Testosterone Deficiency: AUA Guideline', Journal of Urology, vol. 200, no. 2, pp. 423-432. https://doi.org/10.1016/j.juro.2018.03.115
Mulhall JP, Trost LW, Brannigan RE, Kurtz EG, Redmon BB, Chiles KA et al. Evaluation and Management of Testosterone Deficiency: AUA Guideline. Journal of Urology. 2018 Aug 1;200(2):423-432. https://doi.org/10.1016/j.juro.2018.03.115
Mulhall, John P. ; Trost, Landon W. ; Brannigan, Robert E. ; Kurtz, Emily G. ; Redmon, Bruce B ; Chiles, Kelly A. ; Lightner, Deborah J. ; Miner, Martin M. ; Murad, M. Hassan ; Nelson, Christian J. ; Platz, Elizabeth A. ; Ramanathan, Lakshmi V. ; Lewis, Ronald W. / Evaluation and Management of Testosterone Deficiency : AUA Guideline. In: Journal of Urology. 2018 ; Vol. 200, No. 2. pp. 423-432.
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