Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease

Karn Wijarnpreecha, Elizabeth S Aby, Aijaz Ahmed, Donghee Kim

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease and a rapidly growing cause of chronic liver disease in children and adults worldwide. Diagnosis and management of extrahepatic manifestations of NAFLD, including cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, obstructive sleep apnea, polycystic ovarian syndrome, hypothyroidism, psoriasis, and extrahepatic malignancy are crucial for the treatment of patients with NAFLD. The leading cause of death in NAFLD is primarily from CVD, followed by liver-related mortality, extrahepatic cancer, liver cancer, and diabetes-related mortality. Therefore, clinicians need to identify high-risk patients earlier in the disease course and be aware of the extrahepatic manifestations of NAFLD to improve liver disease outcomes. In this review, we focus on the monitoring and management of the extrahepatic manifestations of NAFLD.

Original languageEnglish (US)
Pages (from-to)221-235
Number of pages15
JournalClinical and molecular hepatology
Volume27
Issue number2
DOIs
StatePublished - Apr 2021

Keywords

  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Humans
  • Metabolic Syndrome
  • Non-alcoholic Fatty Liver Disease
  • Renal Insufficiency, Chronic
  • Risk Factors

PubMed: MeSH publication types

  • Journal Article
  • Review

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