Evaluating underlying neuronal activity associated with escape/avoidance behavior in response to noxious stimulation in adult rats

Megan L. Uhelski, Samara A. Morris-Bobzean, Torry S. Dennis, Linda I. Perrotti, Perry N. Fuchs

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The place escape/avoidance paradigm (PEAP) is a behavioral test designed to quantify the level of unpleasantness evoked by painful stimuli by assessing the willingness of a subject to escape/avoid a preferred area when it is associated with noxious stimulation. Previous studies have demonstrated that escape/avoidance behavior is dependent on activity in the anterior cingulate cortex (ACC), a region of the limbic system involved in processing the emotional component of pain in humans and animals. Analysis of c-Fos expression in the ACC confirmed that the escape/avoidance response to noxious stimuli corresponds to changes in neural activation in this region. Behavioral tests such as the PEAP may be more sensitive to changes in supraspinal pain processing and could contribute to the development of novel analgesics in the future.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalBrain Research
Volume1433
DOIs
StatePublished - Jan 18 2012

Keywords

  • Anterior cingulate cortex
  • Carrageenan
  • Inflammatory pain
  • Medial pain system
  • Pain affect
  • Place escape avoidance paradigm

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