Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop

Shannen B. Kizilski; Filippo Coletti; Rumi Faizer; Victor H. Barocas

doi:10.1115/DMD2020-9085

Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop

Shannen B. Kizilski, Filippo Coletti, Rumi Faizer, Victor H. Barocas

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The effect of a double-walled stent-graft (DWSG) design on arterial compliance was evaluated using pulse wave velocity (PWV) measurements in an in vitro mock arterial flow loop. The DWSG prototype was compared to a rigid stent-graft and to an unstented aorta model. The time delay between two pressure sensors a fixed distance apart was used to calculate PWV. Latex tubing simulated the compliant aorta, and a needle valve provided downstream resistance. A series of pulse rates and stroke volumes was applied to enable measurements at different mean pressures for the same system. PWV for the rigid stent-graft was higher than in the other two cases across all mean pressures. The DWSG exhibited behavior similar to the unstented model, demonstrating the capability of the DWSG to maintain aortic compliance in patients requiring an aortic stent-graft.

Original language	English (US)
Title of host publication	Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020
Publisher	American Society of Mechanical Engineers (ASME)
ISBN (Electronic)	9780791883549
DOIs	https://doi.org/10.1115/DMD2020-9085
State	Published - 2020
Event	2020 Design of Medical Devices Conference, DMD 2020 - Minneapolis, United States Duration: Apr 6 2020 → Apr 9 2020

Publication series

Name	Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020

Conference

Conference	2020 Design of Medical Devices Conference, DMD 2020
Country/Territory	United States
City	Minneapolis
Period	4/6/20 → 4/9/20

Bibliographical note

Funding Information:
The authors acknowledge the Anatomy Bequest Program at U. Minnesota for providing the pump used in these experiments. This work was supported by NIH NCATS grants TL1R002493 and UL1TR002494, and NIH NHLBI grant U01HL139471.

Publisher Copyright:
Copyright © 2020 ASME

Keywords

Arterial compliance
Endovascular aortic repair
Pulse wave velocity
Stent-graft design

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1115/DMD2020-9085

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Kizilski, S. B., Coletti, F., Faizer, R., & Barocas, V. H. (2020). Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop. In Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020 (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DMD2020-9085

Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop. / Kizilski, Shannen B.; Coletti, Filippo; Faizer, Rumi et al.
Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), 2020. (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kizilski, SB, Coletti, F, Faizer, R & Barocas, VH 2020, Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop. in Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020, American Society of Mechanical Engineers (ASME), 2020 Design of Medical Devices Conference, DMD 2020, Minneapolis, United States, 4/6/20. https://doi.org/10.1115/DMD2020-9085

Kizilski SB, Coletti F, Faizer R , Barocas VH. Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop. In Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME). 2020. (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020). doi: 10.1115/DMD2020-9085

Kizilski, Shannen B. ; Coletti, Filippo ; Faizer, Rumi et al. / Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop. Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), 2020. (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

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abstract = "The effect of a double-walled stent-graft (DWSG) design on arterial compliance was evaluated using pulse wave velocity (PWV) measurements in an in vitro mock arterial flow loop. The DWSG prototype was compared to a rigid stent-graft and to an unstented aorta model. The time delay between two pressure sensors a fixed distance apart was used to calculate PWV. Latex tubing simulated the compliant aorta, and a needle valve provided downstream resistance. A series of pulse rates and stroke volumes was applied to enable measurements at different mean pressures for the same system. PWV for the rigid stent-graft was higher than in the other two cases across all mean pressures. The DWSG exhibited behavior similar to the unstented model, demonstrating the capability of the DWSG to maintain aortic compliance in patients requiring an aortic stent-graft.",

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note = "Funding Information: The authors acknowledge the Anatomy Bequest Program at U. Minnesota for providing the pump used in these experiments. This work was supported by NIH NCATS grants TL1R002493 and UL1TR002494, and NIH NHLBI grant U01HL139471. Publisher Copyright: Copyright {\textcopyright} 2020 ASME; 2020 Design of Medical Devices Conference, DMD 2020 ; Conference date: 06-04-2020 Through 09-04-2020",

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Evaluating the effect of a double-walled aortic stent-graft prototype on pulse wave velocity in an in vitro flow loop

Abstract

Publication series

Conference

Bibliographical note

Keywords

UN SDGs

Publisher link

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