Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains

Keyphrases

• Bromodomain 100%
• Fragment Library 20%
• Protein-protein Interaction 10%
• Aromatics 10%
• 19F NMR 10%
• X-ray Crystallography 10%
• Structure-activity Relationship Studies 10%
• Bromodomain-containing Protein 4 (BRD4) 10%
• Excellent Selectivity 10%
• Bromodomain Inhibitors 10%
• Fragment-based Drug Discovery 10%
• 3D Character 10%
• Thiazepanes 10%
• Secondary Assays 10%
• Inhibitor Scaffold 10%
• Drug-like 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Structure Activity Relationship 100%
• Bromodomain Inhibitor 100%

Biochemistry, Genetics and Molecular Biology

• Bromodomain 100%
• BPTF 9%
• X-Ray Crystallography 9%
• BRD4 9%
• BRDT 9%
• Protein-Protein Interaction 9%
• Structure Activity Relation 9%