Eut bacterial microcompartments: Insights into their function, structure, and bioengineering applications

Mark Held, Maureen B. Quin, Claudia Schmidt-Dannert

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Bacterial microcompartments (BMCs) are protein-based polyhedral organelles which serve to encapsulate and organize enzymes involved in key metabolic pathways. The sequestration of these pathways not only improves the overall reaction efficiency; it can also harbor toxic or volatile pathway intermediates, which would otherwise be detrimental to the cell. Genomic and phylogenetic analyses reveal the presence of these unique organelles in a diverse range of bacterial species, highlighting their evolutionary importance and the essential role that they play in bacterial cell survival. Functional and structural analyses of BMCs involved in ethanolamine utilization are developing our understanding of the self-assembly and encapsulation mechanisms employed by these protein supercomplexes. This knowledge will open up exciting new avenues of research with a range of potential engineering and biotechnological applications.

Original languageEnglish (US)
Pages (from-to)308-320
Number of pages13
JournalJournal of Molecular Microbiology and Biotechnology
Volume23
Issue number4-5
DOIs
StatePublished - Aug 2013

Keywords

  • Bacterial microcompartments
  • Compartment phylogeny
  • Enzyme targeting
  • Ethanolamine utilization
  • Protein complexes
  • Protein shell

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