Eukaryotic cell dynamics from crawlers to swimmers

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Movement requires force transmission to the environment, and motile cells are robustly, though not elegantly, designed nanomachines that often can cope with a variety of environmental conditions by altering the mode of force transmission used.a As with humans, the available modes range from momentary attachment to a substrate when crawling, to shape deformations when swimming, and at the cellular level this involves sensing the mechanical properties of the environment and altering the mode appropriately. While many types of cells can adapt their mode of movement to their microenvironment (ME), our understanding of how they detect, transduce and process information from the ME to determine the optimal mode is still rudimentary. The shape and integrity of a cell is determined by its cytoskeleton (CSK), and thus the shape changes that may be required to move involve controlled remodeling of the CSK. Motion in vivo is often in response to extracellular signals, which requires the ability to detect such signals and transduce them into the shape changes and force generation needed for movement. Thus the nanomachine is complex, and while much is known about individual components involved in movement, an integrated understanding of motility in even simple cells such as bacteria is not at hand. In this review we discuss recent advances in our understanding of cell motility and some of the problems remaining to be solved. This article is categorized under Structure and Mechanism > Computational Materials Science Structure and Mechanism > Computational Biochemistry and Biophysics.

Original languageEnglish (US)
Article numbere1376
JournalWiley Interdisciplinary Reviews: Computational Molecular Science
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2019

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Eukaryotic Cells
Biophysics
Cytoskeleton
Biochemistry
Cell
Materials science
cells
locomotion
Bacteria
Cell Motility
Mechanical properties
Motility
Remodeling
Materials Science
Substrates
biophysics
biochemistry
Integrity
Mechanical Properties
Cell Movement

Keywords

  • actin dynamics
  • cell motility
  • signal transduction

PubMed: MeSH publication types

  • Journal Article

Cite this

Eukaryotic cell dynamics from crawlers to swimmers. / Othmer, Hans G.

In: Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 9, No. 1, e1376, 01.01.2019.

Research output: Contribution to journalReview article

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