Etv2 as an essential regulator of mesodermal lineage development

Research output: Contribution to journalReview articlepeer-review

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Abstract

The ‘master regulatory factors’ that position at the top of the genetic hierarchy of lineage determination have been a focus of intense interest, and have been investigated in various systems. Etv2/Etsrp71/ER71 is such a factor that is both necessary and sufficient for the development of haematopoietic and endothelial lineages. As such, genetic ablation of Etv2 leads to complete loss of blood and vessels, and overexpression can convert non-endothelial cells to the endothelial lineage. Understanding such master regulatory role of a lineage is not only a fundamental quest in developmental biology, but also holds immense possibilities in regenerative medicine. To harness its activity and utility for therapeutic interventions, it is essential to understand the regulatory mechanisms, molecular function, and networks that surround Etv2. In this review, we provide a comprehensive overview of Etv2 biology focused on mouse and human systems.

Original languageEnglish (US)
Pages (from-to)1294-1306
Number of pages13
JournalCardiovascular Research
Volume113
Issue number11
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
This work was funded by NIH 1R01 HL122576.

Keywords

  • Development
  • ER71
  • Ets transcription factor
  • Etsrp71
  • Etv2
  • Haematopoiesis
  • Vasculogenesis

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