Etiology, pathophysiology of symptoms, and pathogenesis of Meniere's disease

Michael M. Paparella, Hamid R. Djalilian

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


Endolymphatic hydrops is the pathologic feature associated with Meniere's disease. The development of endolymphatic hydrops appears to arise from multifactorial ingeritance with alteration of endolympnatic homeostasis. Various factors associated wih the phenomenon of hydrops include functional or anatomic obstruction of endolympnatic flow, malabsorption of endolymph, genetic anomalies, vasodilation, allergy, viral infection, and autoimmunity.

Original languageEnglish (US)
Pages (from-to)529-545
Number of pages17
JournalOtolaryngologic Clinics of North America
Issue number3
StatePublished - Jun 2002
Externally publishedYes


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