Etiologic connections among substance dependence, antisocial behavior, and personality: Modeling the externalizing spectrum

Robert Krueger, Brian M. Hicks, Christopher J. Patrick, Scott R Carlson, William G Iacono, Matt Mc Gue

Research output: Contribution to journalArticlepeer-review

1001 Scopus citations

Abstract

A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style. The model posits a spectrum of personality and psychopathology, united by an externalizing factor linked to each phenotype within the spectrum, as well as specific factors that account for distinctions among phenotypes within the spectrum. This model fit self-report and mother-report data from 1,048 male and female 17-year-old twins. The variance of the externalizing factor was mostly genetic, but both genetic and environmental factors accounted for distinctions among phenotypes within the spectrum. These results reconcile evidence for general and specific causal factors within the externalizing spectrum and offer the externalizing factor as a novel target for future research.

Original languageEnglish (US)
Pages (from-to)411-424
Number of pages14
JournalJournal of abnormal psychology
Volume111
Issue number3
DOIs
StatePublished - 2002

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