Ethylene Glycol Poisoning: Pharmacokinetics during Therapy with Ethanol and Hemodialysis

Charles D. Peterson; Allan J. Collins; Jon Marc Himes; Milton L. Bullock; William F. Keane

doi:10.1056/NEJM198101013040105

Ethylene Glycol Poisoning: Pharmacokinetics during Therapy with Ethanol and Hemodialysis

Charles D. Peterson
, Allan J. Collins
, Jon Marc Himes
, Milton L. Bullock
, William F. Keane

Medicine - Renal and Hypertension Division

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.¹ ² ³ However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .

Original language	English (US)
Pages (from-to)	21-23
Number of pages	3
Journal	New England Journal of Medicine
Volume	304
Issue number	1
DOIs	https://doi.org/10.1056/NEJM198101013040105
State	Published - Jan 1 1981

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title = "Ethylene Glycol Poisoning: Pharmacokinetics during Therapy with Ethanol and Hemodialysis",

abstract = "THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .",

author = "Peterson, \{Charles D.\} and Collins, \{Allan J.\} and Himes, \{Jon Marc\} and Bullock, \{Milton L.\} and Keane, \{William F.\}",

year = "1981",

month = jan,

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doi = "10.1056/NEJM198101013040105",

language = "English (US)",

volume = "304",

pages = "21--23",

journal = "New England Journal of Medicine",

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TY - JOUR

T1 - Ethylene Glycol Poisoning

T2 - Pharmacokinetics during Therapy with Ethanol and Hemodialysis

AU - Peterson, Charles D.

AU - Collins, Allan J.

AU - Himes, Jon Marc

AU - Bullock, Milton L.

AU - Keane, William F.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .

AB - THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .

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U2 - 10.1056/NEJM198101013040105

DO - 10.1056/NEJM198101013040105

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AN - SCOPUS:0019364187

SN - 0028-4793

VL - 304

SP - 21

EP - 23

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 1

ER -

Ethylene Glycol Poisoning: Pharmacokinetics during Therapy with Ethanol and Hemodialysis

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