Ethylene Glycol Poisoning: Pharmacokinetics during Therapy with Ethanol and Hemodialysis

Charles D. Peterson, Allan J. Collins, Jon Marc Himes, Milton L. Bullock, William F. Keane

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

THE treatment of patients with ethylene glycol poisoning includes both hemodialysis and ethanol.1 2 3 However, there are no data on the pharmacokinetics of ethylene glycol in human beings or on the changes in these kinetics effected by therapy. In a patient who ingested a potentially lethal dose of this toxin, serial determinations of ethylene glycol before and during these therapeutic interventions allowed us to calculate these data. In addition, we determined the oral doses of ethanol needed to achieve effective enzymatic blockade of ethylene glycol metabolism during the various phases of therapy. Case Report A 51-year-old, 75-kg man with no history. . .

Original languageEnglish (US)
Pages (from-to)21-23
Number of pages3
JournalNew England Journal of Medicine
Volume304
Issue number1
DOIs
StatePublished - Jan 1 1981

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