Ethanol induction of acetaminophen toxicity and metabolism

Francis J. Peterson, David E. Holloway, Richard R. Erickson, Peter H. Duquette, Craig J. McClain, Jordan L. Holtzman

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Chronic consumption of moderate amounts of ethanol (10% solution in the drinking water) dramatically enhances the toxicity of acetaminophen in CF-1 mice as demonstrated by a significant decrease in the LD50. The increased toxicity appears to result from an acceleration in the microsomal biotransformation of acetaminophen to a reactive intermediate. Accelerated acetaminophen metabolism in ethanol-treated animals, in turn, causes more rapid depletion of glutathione. These studies suggest a mechanism to account for the toxic synergism between chronic alcohol consumption and acute acetaminophen intake.

Original languageEnglish (US)
Pages (from-to)1705-1711
Number of pages7
JournalLife Sciences
Volume27
Issue number18
DOIs
StatePublished - Jan 1 1980

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