Ethanol induction of acetaminophen toxicity and metabolism

Francis J. Peterson; David E. Holloway; Richard R. Erickson; Peter H. Duquette; Craig J. McClain; Jordan L. Holtzman

doi:10.1016/0024-3205(80)90646-3

Ethanol induction of acetaminophen toxicity and metabolism

Francis J. Peterson, David E. Holloway, Richard R. Erickson, Peter H. Duquette, Craig J. McClain, Jordan L. Holtzman

University of Minnesota Twin Cities

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Abstract

Chronic consumption of moderate amounts of ethanol (10% solution in the drinking water) dramatically enhances the toxicity of acetaminophen in CF-1 mice as demonstrated by a significant decrease in the LD₅₀. The increased toxicity appears to result from an acceleration in the microsomal biotransformation of acetaminophen to a reactive intermediate. Accelerated acetaminophen metabolism in ethanol-treated animals, in turn, causes more rapid depletion of glutathione. These studies suggest a mechanism to account for the toxic synergism between chronic alcohol consumption and acute acetaminophen intake.

Original language	English (US)
Pages (from-to)	1705-1711
Number of pages	7
Journal	Life Sciences
Volume	27
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(80)90646-3
State	Published - Jan 1 1980

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title = "Ethanol induction of acetaminophen toxicity and metabolism",

abstract = "Chronic consumption of moderate amounts of ethanol (10% solution in the drinking water) dramatically enhances the toxicity of acetaminophen in CF-1 mice as demonstrated by a significant decrease in the LD50. The increased toxicity appears to result from an acceleration in the microsomal biotransformation of acetaminophen to a reactive intermediate. Accelerated acetaminophen metabolism in ethanol-treated animals, in turn, causes more rapid depletion of glutathione. These studies suggest a mechanism to account for the toxic synergism between chronic alcohol consumption and acute acetaminophen intake.",

author = "Peterson, {Francis J.} and Holloway, {David E.} and Erickson, {Richard R.} and Duquette, {Peter H.} and McClain, {Craig J.} and Holtzman, {Jordan L.}",

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T1 - Ethanol induction of acetaminophen toxicity and metabolism

AU - Peterson, Francis J.

AU - Holloway, David E.

AU - Erickson, Richard R.

AU - Duquette, Peter H.

AU - McClain, Craig J.

AU - Holtzman, Jordan L.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - Chronic consumption of moderate amounts of ethanol (10% solution in the drinking water) dramatically enhances the toxicity of acetaminophen in CF-1 mice as demonstrated by a significant decrease in the LD50. The increased toxicity appears to result from an acceleration in the microsomal biotransformation of acetaminophen to a reactive intermediate. Accelerated acetaminophen metabolism in ethanol-treated animals, in turn, causes more rapid depletion of glutathione. These studies suggest a mechanism to account for the toxic synergism between chronic alcohol consumption and acute acetaminophen intake.

AB - Chronic consumption of moderate amounts of ethanol (10% solution in the drinking water) dramatically enhances the toxicity of acetaminophen in CF-1 mice as demonstrated by a significant decrease in the LD50. The increased toxicity appears to result from an acceleration in the microsomal biotransformation of acetaminophen to a reactive intermediate. Accelerated acetaminophen metabolism in ethanol-treated animals, in turn, causes more rapid depletion of glutathione. These studies suggest a mechanism to account for the toxic synergism between chronic alcohol consumption and acute acetaminophen intake.

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JO - Life Sciences

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ER -

Ethanol induction of acetaminophen toxicity and metabolism

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