TY - JOUR
T1 - Estrogen-related receptor alpha
T2 - An orphan finds a family
AU - Ochnik, Aleksandra M.
AU - Yee, Douglas
PY - 2012/5/10
Y1 - 2012/5/10
N2 - Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.
AB - Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.
UR - http://www.scopus.com/inward/record.url?scp=84860834823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860834823&partnerID=8YFLogxK
U2 - 10.1186/bcr3124
DO - 10.1186/bcr3124
M3 - Article
C2 - 22574877
AN - SCOPUS:84860834823
SN - 1465-5411
VL - 14
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 3
M1 - 309
ER -