Estrogen-related receptor alpha: An orphan finds a family

Aleksandra M. Ochnik, Douglas Yee

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.

Original languageEnglish (US)
Article number309
JournalBreast Cancer Research
Volume14
Issue number3
DOIs
StatePublished - May 10 2012

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