Estrogen receptor-alpha polymorphism in patients with and without degenerative disease of the temporomandibular joint

Melissa Stemig, Sandra L Myers, Shanti Kaimal, Mohammad Saiful Islam

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Aims: The genetic aspect of degenerative joint disease (DJD) of the temporomandibular joint is poorly understood. The prevalence of the estrogen receptor alpha (ER-alpha) gene polymorphism in patients with and without DJD using xbal and pvull restriction fragment length polymorphisms (RFLPs) was studied. Methodology: DNA samples from 42 DJD+ and 36 DJD- subjects were amplified. A 346-base pair long ERalpha gene fragment containing the two sites of polymorphism in intron 1 was analyzed for xbal and pvull RFLP. Statistical analysis was carried out using Fisher’s exact test and two-group t-test. Results: Five different ER-alpha genotypes were found in both groups. These were PXPX, pxpx, pxPX, PxPX, and pxPx. Discussion: There was a higher number of pxpx and pxPX genotypes in the DJD+ samples compared to the DJD- group, which suggests the presence of polymorphism possibly modulates the ER-alpha activity in bone and contributes to the degenerative process in the joint.

Original languageEnglish (US)
Pages (from-to)129-133
Number of pages5
JournalCranio - Journal of Craniomandibular Practice
Volume33
Issue number2
DOIs
StatePublished - Jan 1 2015

Keywords

  • Degenerative joint disease
  • Estrogen receptor alpha
  • Polymorphism
  • Temporomandibular joint

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