Abstract
There is currently accumulating evidence that endogenous estrogens play a critical role in the development of breast cancer. Estrogens and their metabolites have been studied in both pre- and postmenopausal women with more consistent results shown in the latter population, in part because of large hormonal variations during the menstrual cycle and far fewer studies having been performed in premenopausal women. In this review we describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 231-243 |
| Number of pages | 13 |
| Journal | Cancer Letters |
| Volume | 356 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 28 2015 |
Bibliographical note
Publisher Copyright:© 2014 Elsevier Ireland Ltd.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Breast cancer
- Estrogen
- Estrogen metabolites
- Postmenopausal women
- Premenopausal women
- Sex hormones
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