Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

Daniel P. Zelinski, Nicole Dodge Zantek, Jennifer Walker-Daniels, Mette A. Peters, Elizabeth J. Taparowsky, Michael S. Kinch

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Estrogen receptor and c-Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can increase metastatic potential. We demonstrate, herein, that estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells. These data reveal EphA2 as a downstream target of estrogen and Myc and suggest a mechanism by which estrogen and Myc may regulate breast cancer.

Original languageEnglish (US)
Pages (from-to)714-720
Number of pages7
JournalJournal of Cellular Biochemistry
Volume85
Issue number4
DOIs
StatePublished - May 13 2002

Keywords

  • Anti-estrogens
  • Breast cancer
  • EphA2
  • Estrogen
  • Estrogen receptor
  • Metastasis
  • Myc

Fingerprint Dive into the research topics of 'Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase'. Together they form a unique fingerprint.

Cite this