Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

Daniel P. Zelinski, Nicole Dodge Zantek, Jennifer Walker-Daniels, Mette A. Peters, Elizabeth J. Taparowsky, Michael S. Kinch

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Estrogen receptor and c-Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can increase metastatic potential. We demonstrate, herein, that estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells. These data reveal EphA2 as a downstream target of estrogen and Myc and suggest a mechanism by which estrogen and Myc may regulate breast cancer.

Original languageEnglish (US)
Pages (from-to)714-720
Number of pages7
JournalJournal of Cellular Biochemistry
Issue number4
StatePublished - 2002


  • Anti-estrogens
  • Breast cancer
  • EphA2
  • Estrogen
  • Estrogen receptor
  • Metastasis
  • Myc


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