Estrogen action: Revitalization of the chick oviduct model

Dawne C. Dougherty, Michel M. Sanders

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Despite decades of investigation, the molecular pathways triggered by estrogen that lead to tissue-specific cell proliferation, differentiation and survival are only superficially understood. If we are to modulate the actions of estrogen selectively in these processes, continued investigation using biologically relevant models is essential. The chick oviduct emerged as an early model for investigating the mechanism of action of steroid hormones because of its exquisite responsiveness to them. Unfortunately, because of experimental limitations, this model has been neglected in the past decade. Reviving this model has become intellectually attractive and technically feasible.

Original languageEnglish (US)
Pages (from-to)414-419
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number9
StatePublished - Nov 1 2005

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