Estradiol increases the dendritic length of ventromedial hypothalamic neurons in female syrian hamsters

Robert L. Meisel; Vickie R. Luttrell

doi:10.1016/0361-9230(90)90269-6

Estradiol increases the dendritic length of ventromedial hypothalamic neurons in female syrian hamsters

Robert L. Meisel, Vickie R. Luttrell

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We examined the effects of ovarian hormones on dendritic architecture of neurons in the ventromedial nucleus of the hypothalamus in female Syrian hamsters. Treatment with 10 μg of estradiol benzoate for two days, or estradiol benzoate for two days followed by an injection of 500 μg of progesterone, increased the total dendritic length of ventromedial nucleus neurons by almost 50% compared with neurons from the ventromedial nucleus of ovariectomized, oil-treated females. Neurons in a control region, the dorsomedial nucleus of the hypothalamus, were unaffected by these hormone treatments. These results demonstrate that steroids can induce changes in dendritic structure within 48 hr, suggesting that such morphological reconfiguration of hypothalamic neurons may underlie variations in behavior associated with the female's 4-day estrous cycle.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Brain Research Bulletin
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0361-9230(90)90269-6
State	Published - Jul 1990
Externally published	Yes

Bibliographical note

Funding Information:
This researchw as supportedb y NIH grant HD-21478. We appreciate the assistance of Kimberly Bany in refining the Golgi procedures to optimize staining of ventromedialh ypothalamic neurons. We would also like to thank Sarah Newmana nd Diana Gomez for their invaluable discussions.

Keywords

Dendritic morphology
Estradiol
Female
Syrian hamster

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title = "Estradiol increases the dendritic length of ventromedial hypothalamic neurons in female syrian hamsters",

abstract = "We examined the effects of ovarian hormones on dendritic architecture of neurons in the ventromedial nucleus of the hypothalamus in female Syrian hamsters. Treatment with 10 μg of estradiol benzoate for two days, or estradiol benzoate for two days followed by an injection of 500 μg of progesterone, increased the total dendritic length of ventromedial nucleus neurons by almost 50% compared with neurons from the ventromedial nucleus of ovariectomized, oil-treated females. Neurons in a control region, the dorsomedial nucleus of the hypothalamus, were unaffected by these hormone treatments. These results demonstrate that steroids can induce changes in dendritic structure within 48 hr, suggesting that such morphological reconfiguration of hypothalamic neurons may underlie variations in behavior associated with the female's 4-day estrous cycle.",

keywords = "Dendritic morphology, Estradiol, Female, Syrian hamster",

author = "Meisel, {Robert L.} and Luttrell, {Vickie R.}",

note = "Funding Information: This researchw as supportedb y NIH grant HD-21478. We appreciate the assistance of Kimberly Bany in refining the Golgi procedures to optimize staining of ventromedialh ypothalamic neurons. We would also like to thank Sarah Newmana nd Diana Gomez for their invaluable discussions.",

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AU - Meisel, Robert L.

AU - Luttrell, Vickie R.

N1 - Funding Information: This researchw as supportedb y NIH grant HD-21478. We appreciate the assistance of Kimberly Bany in refining the Golgi procedures to optimize staining of ventromedialh ypothalamic neurons. We would also like to thank Sarah Newmana nd Diana Gomez for their invaluable discussions.

PY - 1990/7

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N2 - We examined the effects of ovarian hormones on dendritic architecture of neurons in the ventromedial nucleus of the hypothalamus in female Syrian hamsters. Treatment with 10 μg of estradiol benzoate for two days, or estradiol benzoate for two days followed by an injection of 500 μg of progesterone, increased the total dendritic length of ventromedial nucleus neurons by almost 50% compared with neurons from the ventromedial nucleus of ovariectomized, oil-treated females. Neurons in a control region, the dorsomedial nucleus of the hypothalamus, were unaffected by these hormone treatments. These results demonstrate that steroids can induce changes in dendritic structure within 48 hr, suggesting that such morphological reconfiguration of hypothalamic neurons may underlie variations in behavior associated with the female's 4-day estrous cycle.

AB - We examined the effects of ovarian hormones on dendritic architecture of neurons in the ventromedial nucleus of the hypothalamus in female Syrian hamsters. Treatment with 10 μg of estradiol benzoate for two days, or estradiol benzoate for two days followed by an injection of 500 μg of progesterone, increased the total dendritic length of ventromedial nucleus neurons by almost 50% compared with neurons from the ventromedial nucleus of ovariectomized, oil-treated females. Neurons in a control region, the dorsomedial nucleus of the hypothalamus, were unaffected by these hormone treatments. These results demonstrate that steroids can induce changes in dendritic structure within 48 hr, suggesting that such morphological reconfiguration of hypothalamic neurons may underlie variations in behavior associated with the female's 4-day estrous cycle.

KW - Dendritic morphology

KW - Estradiol

KW - Female

KW - Syrian hamster

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JF - Brain Research Bulletin

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Estradiol increases the dendritic length of ventromedial hypothalamic neurons in female syrian hamsters

Abstract

Bibliographical note

Keywords

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