Estradiol 17β-dehydrogenase and estradiol binding in human mammary tumors

Y. J. Abul-Hajj, R. Iverson, D. T. Kiang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The metabolism of estradiol was studied in 31 human breast carcinoma in vitro. All 16 estrogen-receptor-poor tumors transformed estradiol to estrone with percent conversions ranging from 11.4 to 95 except for one poorly differentiated tumor where 0.5% conversion to estrone was observed. On the contrary, only 3 out of 15 estrogen-receptor-rich tumors showed higher than 10% conversion of estradiol to estrone (p = 0.001). There is indication that the enzymatic activity in receptor-poor tumors steadily decreases in premenopausal patients as they approach menopausal age, whereas, the activity steadily increases in post-menopausal patients as the duration of menopause lengthens.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalSteroids
Volume33
Issue number4
DOIs
StatePublished - Apr 1979

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