Estimation of Parameters in Binomial Crossover Designs

Chap T Le, O. Gomez‐Marin

Research output: Contribution to journalArticlepeer-review


Maximum Likelihood Estimation of order and treatment effects are derived for Binomial Crossover Designs. All estimators and estimated covariance and variances have closed forms and can be easily evaluated. These results are useful for use in multi‐center clinical trials.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalBiometrical Journal
Issue number2
StatePublished - 1984


  • Binomial Crossover Design
  • Estimation of Parameters
  • Multi‐center Clinical Trials


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