Estimating the cognitive effects of prevalent diabetes, recent onset diabetes, and the duration of diabetes among older adults

Qiong Wu, Eric J. Tchetgen Tchetgen, Theresa Osypuk, Jennifer Weuve, Kellee White, Mahasin Mujahid, M. Maria Glymour

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Little evidence is available on the effects of incident diabetes or diabetes duration on cognitive aging. Methods: We evaluated the effects of prevalent and incident diabetes on deteriorations in cognitive function, based on participants (n = 8,671) aged 65+ in the Health and Retirement Study in 2000. Inverse probability weighting was used to account for selective attrition and time-varying confounding of incident diabetes. Results: Prevalent diabetes predicted higher odds of dementia [odds ratio 1.27; 95% confidence interval (CI) 1.03-1.58] and worse memory (-0.06 in z-score units; 95% CI -0.10 to -0.02), but incident diabetes or diabetes duration up to 8 years of follow-up was not predictive. Conclusion: Prevalent diabetes predicted lower cognition but not recent onset diabetes.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalDementia and Geriatric Cognitive Disorders
Volume39
Issue number3-4
DOIs
StatePublished - Apr 18 2015

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Keywords

  • Cognitive effects
  • Dementia
  • Diabetes duration
  • Prevalent diabetes

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