Esthesioneuroblastoma presenting as sudden unilateral blindness: Histopathologic confirmation of optic nerve demyelination

Eric L. Berman, Alfredo Chu, Jonathan D. Wirtschafter, J. Douglas Cameron, J. Carlos Manivel, Arndt J. Duvall, Stephen J. Haines

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We report here a case of esthesioneuroblastoma an 11-year-old girl presenting as acute loss of vision with minimal evidence of orbital, nasal, or paranasal sinus disease, a rare presenting symptom for this tumor. The initial diagnosis was postviral optic neuritis, a pattern of presentation not previously reported. When vision failed to improve, magnetic resonance imaging revealed a lesion in the posterior ethmoid and sphenoid sinuses. After a biopsy, the tumor was excised through the cranium and paranasal sinuses. A mass completely surrounding the optic nerve without invasion was found. Histochemical staining suggested demyelination secondary to compression, confirming the clinical impression of optic neuritis. Anti-Leu 7 monoclonal antibody is useful in characterizing of this tumor, since other immunochemical stains can be misleading. Radiation and chemotherapy were given after the tumor was removed. Two years later, the patient has had neither recurrence nor complications.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalJournal of Clinical Neuro-Ophthalmology
Volume12
Issue number1
StatePublished - Mar 1992

Keywords

  • Anti-Leu 7 monoclonal antibody
  • Esthesioneuroblastoma
  • Postviral optic neuritis

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