Esophageal carcinoma with a rhabdoid phenotype: A case report of diagnosis by endoscopic ultrasound-guided fine-needle aspiration

Linda R. Varghese, Michael W. Stanley, Mary Lynne Lucido, James S Mallery, Rebecca Lai, Ricardo H. Bardales

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Malignant extra renal tumors with rhabdoid phenotype are aggressive neoplasms associated with a poor prognosis. These tumors have been reported in soft tissue and various organs including the gastrointestinal tract. We report one of such tumors arising in the esophagus and discuss the cytopathologic, immunohistochemical, and ultrastructural features. Endoscopic ultrasound-guided fine-needle aspiration (FNA) cytology revealed a highly cellular tumor, consisting of polygonal poorly cohesive cells with prominent eosinophilic paranuclear cytoplasmic inclusions. Immunohistochemical staining showed strong cytoplasmic positivity for vimentin and cytokeratin. Electron microscopy revealed presence of numerous intermediate filaments. To the best of our knowledge, this is the first example of carcinoma with rhabdoid phenotype of the esophagus diagnosed by FNA cytology.

Original languageEnglish (US)
Pages (from-to)407-411
Number of pages5
JournalDiagnostic Cytopathology
Volume33
Issue number6
DOIs
StatePublished - Dec 1 2005

Keywords

  • Cytology
  • Endoscopic ultrasound
  • Esophagus
  • Fine-needle aspiration
  • Rhabdoid tumor

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