TY - JOUR
T1 - Escherichia coli O157
T2 - Insights into the adaptive stress physiology and the influence of stressors on epidemiology and ecology of this human pathogen
AU - Vidovic, Sinisa
AU - Korber, Darren R.
PY - 2016/1/2
Y1 - 2016/1/2
N2 - Escherichia coli O157, a foodborne pathogen of major concern for public health, has been associated with numerous outbreaks of haemorrhagic colitis and hemolytic uremic syndrome worldwide. Human infection with E. coli O157 has been primarily associated with the food-chain transmission route. This transmission route commonly elicits a multi-faceted adaptive stress response of E. coli O157 for an extended period of time prior to human infection. Several recent research articles have indicated that E. coli O157:H7 has evolved unique survival characteristics which can affect the epidemiology and ecology of this zoonotic pathogen. This review article summarizes the recent knowledge of the molecular responses of E. coli O157 to the most common stressors found within the human food chain, and further emphasizes the influence of these stressors on the epidemiology and ecology of E. coli O157.
AB - Escherichia coli O157, a foodborne pathogen of major concern for public health, has been associated with numerous outbreaks of haemorrhagic colitis and hemolytic uremic syndrome worldwide. Human infection with E. coli O157 has been primarily associated with the food-chain transmission route. This transmission route commonly elicits a multi-faceted adaptive stress response of E. coli O157 for an extended period of time prior to human infection. Several recent research articles have indicated that E. coli O157:H7 has evolved unique survival characteristics which can affect the epidemiology and ecology of this zoonotic pathogen. This review article summarizes the recent knowledge of the molecular responses of E. coli O157 to the most common stressors found within the human food chain, and further emphasizes the influence of these stressors on the epidemiology and ecology of E. coli O157.
KW - Escherichia coli O157
KW - homeoviscous adaptation
KW - molecular chaperones
KW - public health
KW - stress response
UR - http://www.scopus.com/inward/record.url?scp=84959319447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959319447&partnerID=8YFLogxK
U2 - 10.3109/1040841X.2014.889654
DO - 10.3109/1040841X.2014.889654
M3 - Review article
C2 - 24601836
AN - SCOPUS:84959319447
VL - 42
SP - 83
EP - 93
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
SN - 1040-841X
IS - 1
ER -