Erythrocyte (Ca+2+Mg+2)‐ATPase activity: Increased sensitivity to oxidative stress in glucose‐6‐phosphate dehydrogenase deficiency

Oded Shalev, Vardiella Lavi, Robert P Hebbel, John W. Eaton

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effect of the thiol‐oxidizing agent diamide on erythrocyte (Ca+2+Mg+2)‐ATPase activity was measured in normal and glucose‐6‐phosphate‐dehydrogenase‐deficient (G6PD) cells. Although the enzyme activity before the oxidative stress was similar in both groups, diamide induced a markedly greater inhibition in the enzyme activity in the G6PD cells than in the normal controls. These data indicate dependence of erythrocyte (Ca+2+Mg+2)‐ATPase, in part, on the redox status of the cell. The increased vulnerability of (Ca+2+Mg+2)ATPase to oxidative stress in G6PD may be of pathophysiological relevance to their premature destruction in oxidant‐induced hemolysis.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalAmerican Journal of Hematology
Volume19
Issue number2
DOIs
StatePublished - Jun 1985

Keywords

  • adenosine triphosphatase
  • calcium
  • erythrocytes
  • glucose‐6‐phosphate dehydrogenase

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