Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period

Julio Alvarez, Andres M. Perez, Javier Bezos, Carmen Casal, Beatriz Romero, Sabrina Rodriguez-Campos, Jose L. Saez-Llorente, Rosa Diaz, Jesus Carpintero, Lucia de Juan, Lucas Domínguez

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Background: Eradication of bovine tuberculosis (bTB) through the application of test-and-cull programs is a declared goal of developed countries in which the disease is still endemic. Here, longitudinal data from more than 1,700 cattle herds tested during a 12 year-period in the eradication program in the region of Madrid, Spain, were analyzed to quantify the within-herd transmission coefficient (β) depending on the herd-type (beef/dairy/bullfighting). In addition, the probability to recover the officially bTB free (OTF) status in infected herds depending on the type of herd and the diagnostic strategy implemented was assessed using Cox proportional hazard models.Results: Overall, dairy herds showed higher β (median 4.7) than beef or bullfighting herds (2.3 and 2.2 respectively). Introduction of interferon-gamma (IFN-γ) as an ancillary test produced an apparent increase in the β coefficient regardless of production type, likely due to an increase in diagnostic sensitivity. Time to recover OTF status was also significantly lower in dairy herds, and length of bTB episodes was significantly reduced when the IFN-γ was implemented to manage the outbreak.Conclusions: Our results suggest that bTB spreads more rapidly in dairy herds compared to other herd types, a likely cause being management and demographic-related factors. However, outbreaks in dairy herds can be controlled more rapidly than in typically extensive herd types. Finally, IFN-γ proved its usefulness to rapidly eradicate bTB at a herd-level.

Original languageEnglish (US)
Article number100
JournalBMC Veterinary Research
StatePublished - Jun 29 2012
Externally publishedYes

Bibliographical note

Funding Information:
The authors are grateful to all the field veterinarians that have participated in the tuberculosis eradication campaign in the last 12 years, to L. Pazos for his help in the management of the database, to S. Gonzalez for his help on figure editing and to M. Gilmour for revision of the manuscript. This research was funded by European Project 212414 “Strategies for the eradication of bovine tuberculosis (TBSTEP)”. Julio Alvarez is the recipient of a post-doctoral grant of the University of Castilla la Mancha (UCLM) and was partially funded by a grant of the program Iberoamerica of Santander Universities (2011).


Dive into the research topics of 'Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period'. Together they form a unique fingerprint.

Cite this