Equine proliferative enteropathy caused by Lawsonia intracellularis

N. Pusterla, C. Gebhart

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Equine proliferative enteropathy (EPE) is a disease of foals caused by the obligate intracellular organism Lawsonia intracellularis. This emerging disease affects mainly weanling foals and causes fever, lethargy, peripheral oedema, diarrhoea, colic and weight loss. The diagnosis of EPE may be challenging and relies on the presence of hypoproteinaemia, thickening of segments of the small intestinal wall observed on abdominal ultrasonography, positive serology and molecular detection of L. intracellularis in faeces. Although the clinical entity, diagnostic work-up and treatment of EPE are well established and described, the epidemiology for this disease has remained largely unaddressed. This article reviews the aetiology, epidemiology, clinical signs, diagnosis, treatment and prevention of EPE.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalEquine Veterinary Education
Issue number8
StatePublished - Aug 2009


  • Clinical signs
  • Diagnosis
  • Horse
  • Lawsonia intracellularis
  • Proliferative enteropathy
  • Treatment


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