Equine developmental orthopaedic diseases - A genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters

S. Lykkjen; N. I. Dolvik; M. E. McCue; A. K. Rendahl; J. R. Mickelson; K. H. Røed

doi:10.1111/age.12064

Equine developmental orthopaedic diseases - A genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters

S. Lykkjen, N. I. Dolvik, M. E. McCue, A. K. Rendahl, J. R. Mickelson, K. H. Røed

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Abstract

Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.

Original language	English (US)
Pages (from-to)	766-769
Number of pages	4
Journal	Animal Genetics
Volume	44
Issue number	6
DOIs	https://doi.org/10.1111/age.12064
State	Published - Dec 2013

Keywords

Equine SNP50 BeadChip®
horse
osteochondrosis
palmar/plantar osteochondral fragments
quantitative trait loci

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10.1111/age.12064

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title = "Equine developmental orthopaedic diseases - A genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters",

abstract = "Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip{\textregistered} to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.",

keywords = "Equine SNP50 BeadChip{\textregistered}, horse, osteochondrosis, palmar/plantar osteochondral fragments, quantitative trait loci",

author = "S. Lykkjen and Dolvik, {N. I.} and McCue, {M. E.} and Rendahl, {A. K.} and Mickelson, {J. R.} and R{\o}ed, {K. H.}",

year = "2013",

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volume = "44",

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AU - Lykkjen, S.

AU - Dolvik, N. I.

AU - McCue, M. E.

AU - Rendahl, A. K.

AU - Mickelson, J. R.

AU - Røed, K. H.

PY - 2013/12

Y1 - 2013/12

N2 - Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.

AB - Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.

KW - Equine SNP50 BeadChip®

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KW - osteochondrosis

KW - palmar/plantar osteochondral fragments

KW - quantitative trait loci

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Equine developmental orthopaedic diseases - A genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters

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