Equine developmental orthopaedic diseases - A genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters

S. Lykkjen, N. I. Dolvik, M. E. McCue, A. K. Rendahl, J. R. Mickelson, K. H. Røed

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.

Original languageEnglish (US)
Pages (from-to)766-769
Number of pages4
JournalAnimal Genetics
Volume44
Issue number6
DOIs
StatePublished - Dec 2013

Keywords

  • Equine SNP50 BeadChip®
  • horse
  • osteochondrosis
  • palmar/plantar osteochondral fragments
  • quantitative trait loci

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