Epstein–Barr Virus-Induced B-Cell Lymphoma after Renal Transplantation: Acyclovir Therapy and Transition from Polyclonal to Monoclonal B-Cell Proliferation

D. W. Hanto, G. Frizzera, K. J. Gajl-Peczalska, K. Sakamoto, D. T. Purtilo, H. H. Balfour, R. L. Simmons, J. S. Najarian

Research output: Contribution to journalArticle

340 Scopus citations

Abstract

THE Epstein–Barr virus (EBV) is a transforming herpesvirus that selectively infects B lymphocytes, causes infectious mononucleosis,1 and may have a role in the development of Burkitt's lymphoma,2 nasopharyngeal carcinoma,3 and the lymphoid disorders arising in Duncan's disease.4 EBV has recently been implicated in the pathogenesis of the lymphoproliferative diseases occurring in immunosuppressed recipients of organ transplants.5 These disorders can be characterized morphologically as either polymorphic diffuse B-cell hyperplasia or polymorphic B-cell lymphoma.6 On histologic grounds they can be differentiated from infectious mononucleosis, other reactive lymphoid hyperplasias, immunoblastic B-cell sarcoma, and Burkitt's lymphoma.6 Polymorphic diffuse B-cell hyperplasia and polymorphic B-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)913-918
Number of pages6
JournalNew England Journal of Medicine
Volume306
Issue number15
DOIs
StatePublished - Apr 15 1982

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