TY - JOUR
T1 - Epstein–Barr Virus-Induced B-Cell Lymphoma after Renal Transplantation
T2 - Acyclovir Therapy and Transition from Polyclonal to Monoclonal B-Cell Proliferation
AU - Hanto, D. W.
AU - Frizzera, G.
AU - Gajl-Peczalska, K. J.
AU - Sakamoto, K.
AU - Purtilo, D. T.
AU - Balfour, H. H.
AU - Simmons, R. L.
AU - Najarian, J. S.
PY - 1982/4/15
Y1 - 1982/4/15
N2 - THE Epstein–Barr virus (EBV) is a transforming herpesvirus that selectively infects B lymphocytes, causes infectious mononucleosis,1 and may have a role in the development of Burkitt's lymphoma,2 nasopharyngeal carcinoma,3 and the lymphoid disorders arising in Duncan's disease.4 EBV has recently been implicated in the pathogenesis of the lymphoproliferative diseases occurring in immunosuppressed recipients of organ transplants.5 These disorders can be characterized morphologically as either polymorphic diffuse B-cell hyperplasia or polymorphic B-cell lymphoma.6 On histologic grounds they can be differentiated from infectious mononucleosis, other reactive lymphoid hyperplasias, immunoblastic B-cell sarcoma, and Burkitt's lymphoma.6 Polymorphic diffuse B-cell hyperplasia and polymorphic B-cell lymphoma.
AB - THE Epstein–Barr virus (EBV) is a transforming herpesvirus that selectively infects B lymphocytes, causes infectious mononucleosis,1 and may have a role in the development of Burkitt's lymphoma,2 nasopharyngeal carcinoma,3 and the lymphoid disorders arising in Duncan's disease.4 EBV has recently been implicated in the pathogenesis of the lymphoproliferative diseases occurring in immunosuppressed recipients of organ transplants.5 These disorders can be characterized morphologically as either polymorphic diffuse B-cell hyperplasia or polymorphic B-cell lymphoma.6 On histologic grounds they can be differentiated from infectious mononucleosis, other reactive lymphoid hyperplasias, immunoblastic B-cell sarcoma, and Burkitt's lymphoma.6 Polymorphic diffuse B-cell hyperplasia and polymorphic B-cell lymphoma.
UR - http://www.scopus.com/inward/record.url?scp=0020471814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020471814&partnerID=8YFLogxK
U2 - 10.1056/NEJM198204153061506
DO - 10.1056/NEJM198204153061506
M3 - Article
C2 - 6278307
AN - SCOPUS:0020471814
SN - 0028-4793
VL - 306
SP - 913
EP - 918
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 15
ER -