Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH.
Original language | English (US) |
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Pages (from-to) | 915-920 |
Number of pages | 6 |
Journal | Journal of neuropathology and experimental neurology |
Volume | 79 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2020 |
Bibliographical note
Publisher Copyright:© 2020 American Association of Neuropathologists, Inc. All rights reserved.
Keywords
- Epstein Barr virus (EBV)
- Hemophagocytic lymphohistiocytosis (HLH)
PubMed: MeSH publication types
- Case Reports
- Journal Article