Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of neuropathology and experimental neurology|
|State||Published - Aug 1 2020|
Bibliographical notePublisher Copyright:
© 2020 American Association of Neuropathologists, Inc. All rights reserved.
- Epstein Barr virus (EBV)
- Hemophagocytic lymphohistiocytosis (HLH)