TY - JOUR
T1 - Epstein virus Barr-positive diffuse large B-Cell lymphoma associated with hemophagocytic lymphohistiocytosis
AU - Ricard, Jocelyn A.
AU - Charles, River
AU - Tommee, Carolina Gil
AU - Yohe, Sophia
AU - Robert Bell, W.
AU - Flanagan, Margaret E.
N1 - Publisher Copyright:
© 2020 American Association of Neuropathologists, Inc. All rights reserved.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH.
AB - Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH.
KW - Epstein Barr virus (EBV)
KW - Hemophagocytic lymphohistiocytosis (HLH)
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U2 - 10.1093/jnen/nlaa061
DO - 10.1093/jnen/nlaa061
M3 - Article
C2 - 32647871
AN - SCOPUS:85088495735
SN - 0022-3069
VL - 79
SP - 915
EP - 920
JO - Journal of neuropathology and experimental neurology
JF - Journal of neuropathology and experimental neurology
IS - 8
ER -
