Abstract
Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1309-1318 |
| Number of pages | 10 |
| Journal | International Journal of Biological Sciences |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| State | Published - Oct 18 2016 |
Bibliographical note
Publisher Copyright:© Ivyspring International Publisher.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Carcinogenesis
- Epstein-Barr virus
- Latency
- Reactivation
- Rta
- Zta
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