Epstein-barr virus and the somatic hypermutation of immunoglobulin genes in burkitt's lymphoma cells

R. S. Harris, D. S G Croom-Carter, A. B. Rickinson, M. S. Neuberger

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

It has been suggested that Epstein-Barr virus (EBV) might suppress antibody maturation either by facilitating bypass of the germinal center reaction or by inhibiting hypermutation directly. However, by infecting the Burkitt's lymphoma (BL) cell line Ramos, which hypermutates constitutively and can be considered a transformed analogue of a germinal center B cell, with EBV as well as by transfecting it with selected EBV latency genes, we demonstrate that expression of EBV gene products does not lead to an inhibition of hypermutation. Moreover, we have identified two natural EBV-positive BL cell lines (ELI-BL and BL16) that hypermutate constitutively. Thus, contrary to expectations, EBV gene products do not appear to affect somatic hypermutation.

Original languageEnglish (US)
Pages (from-to)10488-10492
Number of pages5
JournalJournal of virology
Volume75
Issue number21
DOIs
StatePublished - 2001

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