Epithelial downgrowth after Descemet-stripping automated endothelial keratoplasty

Paul M. Phillips; Mark A. Terry; Stephen C. Kaufman; Edwin S. Chen

doi:10.1016/j.jcrs.2008.07.036

Epithelial downgrowth after Descemet-stripping automated endothelial keratoplasty

Paul M. Phillips, Mark A. Terry, Stephen C. Kaufman, Edwin S. Chen

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A 66-year-old man presented with decreased vision and corneal edema after 2 failed Descemet-stripping automated endothelial keratoplasty (DSAEK) graft procedures in the left eye. An uneventful third DSAEK procedure combined with anterior vitrectomy through the previous limbal wound was performed. Postoperative recovery was uneventful. Histopathology of the excised failed graft revealed conjunctival epithelium on the posterior surface of the tissue. At 1 year, the endothelial cell count was 1997 cells/mm² and the uncorrected visual acuity was 20/20^-2. At 18 months, the graft remained clear with no signs of epithelial downgrowth. Clinicians should be aware that epithelial downgrowth can occur following DSAEK surgery. Fortunately, excision of the prior DSAEK graft with removal of the active epithelial membrane appears to have been a successful treament in this patient.

Original language	English (US)
Pages (from-to)	193-196
Number of pages	4
Journal	Journal of cataract and refractive surgery
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.jcrs.2008.07.036
State	Published - Jan 2009
Externally published	Yes

Bibliographical note

Funding Information:
Supported in part by an unrestricted grant from Research to Prevent Blindness, New York, New York, USA.

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10.1016/j.jcrs.2008.07.036

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title = "Epithelial downgrowth after Descemet-stripping automated endothelial keratoplasty",

abstract = "A 66-year-old man presented with decreased vision and corneal edema after 2 failed Descemet-stripping automated endothelial keratoplasty (DSAEK) graft procedures in the left eye. An uneventful third DSAEK procedure combined with anterior vitrectomy through the previous limbal wound was performed. Postoperative recovery was uneventful. Histopathology of the excised failed graft revealed conjunctival epithelium on the posterior surface of the tissue. At 1 year, the endothelial cell count was 1997 cells/mm2 and the uncorrected visual acuity was 20/20-2. At 18 months, the graft remained clear with no signs of epithelial downgrowth. Clinicians should be aware that epithelial downgrowth can occur following DSAEK surgery. Fortunately, excision of the prior DSAEK graft with removal of the active epithelial membrane appears to have been a successful treament in this patient.",

author = "Phillips, {Paul M.} and Terry, {Mark A.} and Kaufman, {Stephen C.} and Chen, {Edwin S.}",

note = "Funding Information: Supported in part by an unrestricted grant from Research to Prevent Blindness, New York, New York, USA. ",

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AU - Phillips, Paul M.

AU - Terry, Mark A.

AU - Kaufman, Stephen C.

AU - Chen, Edwin S.

N1 - Funding Information: Supported in part by an unrestricted grant from Research to Prevent Blindness, New York, New York, USA.

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N2 - A 66-year-old man presented with decreased vision and corneal edema after 2 failed Descemet-stripping automated endothelial keratoplasty (DSAEK) graft procedures in the left eye. An uneventful third DSAEK procedure combined with anterior vitrectomy through the previous limbal wound was performed. Postoperative recovery was uneventful. Histopathology of the excised failed graft revealed conjunctival epithelium on the posterior surface of the tissue. At 1 year, the endothelial cell count was 1997 cells/mm2 and the uncorrected visual acuity was 20/20-2. At 18 months, the graft remained clear with no signs of epithelial downgrowth. Clinicians should be aware that epithelial downgrowth can occur following DSAEK surgery. Fortunately, excision of the prior DSAEK graft with removal of the active epithelial membrane appears to have been a successful treament in this patient.

AB - A 66-year-old man presented with decreased vision and corneal edema after 2 failed Descemet-stripping automated endothelial keratoplasty (DSAEK) graft procedures in the left eye. An uneventful third DSAEK procedure combined with anterior vitrectomy through the previous limbal wound was performed. Postoperative recovery was uneventful. Histopathology of the excised failed graft revealed conjunctival epithelium on the posterior surface of the tissue. At 1 year, the endothelial cell count was 1997 cells/mm2 and the uncorrected visual acuity was 20/20-2. At 18 months, the graft remained clear with no signs of epithelial downgrowth. Clinicians should be aware that epithelial downgrowth can occur following DSAEK surgery. Fortunately, excision of the prior DSAEK graft with removal of the active epithelial membrane appears to have been a successful treament in this patient.

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Epithelial downgrowth after Descemet-stripping automated endothelial keratoplasty

Abstract

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