Epistasis and hybrid sterility in Saccharomyces

Duncan Greig, Rhona H. Borts, Edward J. Louis, Michael Travisano

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


Hybrid sterility is thought to be due to deleterious epistatic interactions between genes from different species. Here we demonstrate that dominant genic incompatibility does not contribute to sterility in hybrids between Saccharomyces cerevisiae and five closely related species. Sterile diploids were made fertile by genome doubling to produce hybrid tetraploids. Based on these and previous results, we conclude that neither genic incompatibility nor classical chromosomal speciation models apply.

Original languageEnglish (US)
Pages (from-to)1167-1171
Number of pages5
JournalProceedings of the Royal Society B: Biological Sciences
Issue number1496
StatePublished - Jun 7 2002


  • Evolution
  • Meiosis
  • Speciation
  • Tetraploid
  • Yeast


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