Epinephrine reduction of heme: Implication for understanding the transmission of an agonist stimulus

Douglas A. Peterson, Jonathan M. Gerrard, Sheila M. Glover, Gundu H.R. Rao, James G. White

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.

Original languageEnglish (US)
Pages (from-to)71-73
Number of pages3
JournalScience
Volume215
Issue number4528
DOIs
StatePublished - 1982

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