Epinephrine reduction of heme: Implication for understanding the transmission of an agonist stimulus

Douglas A. Peterson; Jonathan M. Gerrard; Sheila M. Glover; Gundu H.R. Rao; James G. White

doi:10.1126/science.6274020

Epinephrine reduction of heme: Implication for understanding the transmission of an agonist stimulus

Douglas A. Peterson, Jonathan M. Gerrard, Sheila M. Glover, Gundu H.R. Rao, James G. White

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.

Original language	English (US)
Pages (from-to)	71-73
Number of pages	3
Journal	Science
Volume	215
Issue number	4528
DOIs	https://doi.org/10.1126/science.6274020
State	Published - 1982
Externally published	Yes

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title = "Epinephrine reduction of heme: Implication for understanding the transmission of an agonist stimulus",

abstract = "Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.",

author = "Peterson, {Douglas A.} and Gerrard, {Jonathan M.} and Glover, {Sheila M.} and Rao, {Gundu H.R.} and White, {James G.}",

year = "1982",

doi = "10.1126/science.6274020",

language = "English (US)",

volume = "215",

pages = "71--73",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4528",

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T1 - Epinephrine reduction of heme

T2 - Implication for understanding the transmission of an agonist stimulus

AU - Peterson, Douglas A.

AU - Gerrard, Jonathan M.

AU - Glover, Sheila M.

AU - Rao, Gundu H.R.

AU - White, James G.

PY - 1982

Y1 - 1982

N2 - Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.

AB - Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.

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U2 - 10.1126/science.6274020

DO - 10.1126/science.6274020

M3 - Article

C2 - 6274020

AN - SCOPUS:0020084927

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VL - 215

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JO - Science

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ER -

Epinephrine reduction of heme: Implication for understanding the transmission of an agonist stimulus

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