Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported widely in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.
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Conflicts of Interest: All authors have read the journal's policy on disclosure of potential conflicts of interest and have none to declare. This work was supported by the National Institutes of Health ( R01CA100679 and R01CA126939 to KTK; and K22CA172358 to SML).