Epigenetics of lung cancer

Scott M. Langevin, Robert A. Kratzke, Karl T. Kelsey

Research output: Contribution to journalReview article

73 Scopus citations

Abstract

Lung cancer is the leading cause of cancer-related mortality in the United States. Epigenetic alterations, including DNA methylation, histone modifications, and noncoding RNA expression, have been reported widely in the literature to play a major role in the genesis of lung cancer. The goal of this review is to summarize the common epigenetic changes associated with lung cancer to give some clarity to its etiology, and to provide an overview of the potential translational applications of these changes, including applications for early detection, diagnosis, prognostication, and therapeutics.

Original languageEnglish (US)
Pages (from-to)74-90
Number of pages17
JournalTranslational Research
Volume165
Issue number1
DOIs
StatePublished - Jan 1 2015

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Langevin, S. M., Kratzke, R. A., & Kelsey, K. T. (2015). Epigenetics of lung cancer. Translational Research, 165(1), 74-90. https://doi.org/10.1016/j.trsl.2014.03.001