Epigenetics advancing personalized nanomedicine in cancer therapy

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Personalized medicine aims to deliver the right drug to a right patient at the right time. It offers unique opportunities to integrate new technologies and concepts to disease prognosis, diagnosis and therapeutics. While selective personalized therapies are conceptually impressive, the majority of cancer therapies have dismal outcome. Such therapeutic failure could result from no response, drug resistance, disease relapse or severe side effect from improper drug delivery. Nanomedicine, the application of nanotechnology in medicine, has a potential to advance the identification of diagnostic and prognostic biomarkers and the delivery of right drug to disease sites. Epigenetic aberrations dynamically contribute to cancer pathogenesis. Given the individualized traits of epigenetic biomarkers, epigenetic considerations would significantly refine personalized nanomedicine. This review aims to dissect the interface of personalized medicine with nanomedicine and epigenetics. I will outline the progress and highlight challenges and areas that can be further explored perfecting the personalized health care.

Original languageEnglish (US)
Pages (from-to)1532-1543
Number of pages12
JournalAdvanced Drug Delivery Reviews
Volume64
Issue number13
DOIs
StatePublished - Oct 2012

Keywords

  • 5hmC
  • 5mC
  • ABC
  • AML
  • ATP
  • BCR
  • BRCA1
  • Biomarkers
  • CBFβ
  • CBP
  • CML
  • CREB
  • DNMT
  • DOX
  • Drug delivery
  • EGFR
  • ER
  • ETO
  • Epigenetics
  • ErbB2
  • FHIT
  • FLT3
  • GSTP1
  • HAT
  • HDAC
  • HDMT
  • HER2
  • HGP
  • HMT
  • IDH
  • IL-3
  • MDS
  • MOZ
  • MRI
  • MZ
  • MiRs
  • Nanomedicine
  • Nanoparticles
  • Nanotechnology
  • PI3K
  • PZLF
  • Personalized medicine
  • Personalized nanomedicine
  • RAR-α
  • RASSF1A
  • SAM
  • SMMHC
  • SNPs
  • TET
  • TSGs
  • Targeted therapy
  • UTRs
  • VMRs
  • WWOX

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