Epigenetics advancing personalized nanomedicine in cancer therapy

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29 Scopus citations


Personalized medicine aims to deliver the right drug to a right patient at the right time. It offers unique opportunities to integrate new technologies and concepts to disease prognosis, diagnosis and therapeutics. While selective personalized therapies are conceptually impressive, the majority of cancer therapies have dismal outcome. Such therapeutic failure could result from no response, drug resistance, disease relapse or severe side effect from improper drug delivery. Nanomedicine, the application of nanotechnology in medicine, has a potential to advance the identification of diagnostic and prognostic biomarkers and the delivery of right drug to disease sites. Epigenetic aberrations dynamically contribute to cancer pathogenesis. Given the individualized traits of epigenetic biomarkers, epigenetic considerations would significantly refine personalized nanomedicine. This review aims to dissect the interface of personalized medicine with nanomedicine and epigenetics. I will outline the progress and highlight challenges and areas that can be further explored perfecting the personalized health care.

Original languageEnglish (US)
Pages (from-to)1532-1543
Number of pages12
JournalAdvanced Drug Delivery Reviews
Issue number13
StatePublished - Oct 2012

Bibliographical note

Funding Information:
This work was supported partially by the NIH grants R01CA149623 (S. Liu), R21CA155915 (S. Liu) and Hormel Foundation (S. Liu). The author specifically thanks Drs. Lai-Chu Wu and Sudha Agarwal at the Ohio State University for their much appreciated assistance in proof-reading and editing this manuscript and picture. The author is grateful to Drs. Robert J. Lee and L. James Lee at the Ohio State University and Dr. Wei Ding at Mayo Clinic for their valuable thoughts, criticisms and insights.


  • 5hmC
  • 5mC
  • ABC
  • AML
  • ATP
  • BCR
  • BRCA1
  • Biomarkers
  • CBFβ
  • CBP
  • CML
  • CREB
  • DNMT
  • DOX
  • Drug delivery
  • EGFR
  • ER
  • ETO
  • Epigenetics
  • ErbB2
  • FHIT
  • FLT3
  • GSTP1
  • HAT
  • HDAC
  • HDMT
  • HER2
  • HGP
  • HMT
  • IDH
  • IL-3
  • MDS
  • MOZ
  • MRI
  • MZ
  • MiRs
  • Nanomedicine
  • Nanoparticles
  • Nanotechnology
  • PI3K
  • PZLF
  • Personalized medicine
  • Personalized nanomedicine
  • RAR-α
  • SAM
  • SNPs
  • TET
  • TSGs
  • Targeted therapy
  • UTRs
  • VMRs
  • WWOX


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